To use all site features Login or Create a User Account

Search eNews

From
Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 2005 2006 2007 2008 2009 2010

To
Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 2005 2006 2007 2008 2009 2010

eNews from Friday, January 16, 2009

Soy Protein, Phytosterols Increase Effectiveness of Mediterranean-Style Diet on Metabolic Syndrome, CVD Risk Factors: New Study

TB & Outbreaks Week: Expanded Reporting -- 2009 JAN 20 - (NewsRx.com) -- "As the worldwide dietary pattern becomes more westernized, the metabolic syndrome is reaching epidemic proportions (see also http://www.newsrx.com/library/topics/Phytochemicals.html). Lifestyle modifications including diet and exercise are recommended as first-line intervention for treating metabolic syndrome," scientists writing in the journal Nutrition & Metabolism report.

"Previously, we reported that a modified Mediterranean-style, low glycemic load diet with soy protein and phytosterols had a more favorable impact than the American Heart Association Step 1 diet on cardiovascular disease (CVD) risk factors. Subsequently, we screened for phytochemicals with a history of safe use that were capable of increasing insulin sensitivity through modulation of protein kinases, and identified hops rho iso-alpha acid and acacia proanthocyanidins. The objective of this study was to investigate whether enhancement of a modified Mediterranean-style, low glycemic load diet (MED) with specific phytochemicals (soy protein, phytosterols, rho iso-alpha acids and proanthocyanidins; PED) could improve cardiometabolic risk factors in subjects with metabolic syndrome and hypercholesterolemia. Forty-nine subjects with metabolic syndrome and hypercholesterolemia, aged 25-80, entered a randomized, 2-arm, 12-week intervention trial; 23 randomized to the MED arm; 26 to the PED arm. Forty-four subjects completed at least 8 weeks [MED (n = 19); PED (n = 25)]. All subjects were instructed to follow the same aerobic exercise program. Three-day diet diaries and 7-day exercise diaries were assessed at each visit. Fasting blood samples were collected at baseline, 8 and 12 weeks for analysis. Both arms experienced equal weight loss (MED: -5.7 kg; PED: -5.9 kg). However, at 12 weeks, the PED arm experienced greater reductions (P < 0.05) in cholesterol, non-HDL cholesterol, triglycerides (TG), cholesterol/HDL and TG/HDL compared with the MED arm. Only the PED arm experienced increased HDL (P < 0.05) and decreased TG/HDL (P < 0.01), and continued reduction in apo B/apo A-1 from 8 to 12 weeks. Furthermore, 43% of PED subjects vs. only 22% of MED subjects had net resolution of metabolic syndrome. The Framingham 10-year CVD risk score decreased by 5.6% in the PED arm (P < 0.01) and 2.9% in the MED arm (P < 0.05)," wrote R.H. Lerman and colleagues.

The researchers concluded: "These results demonstrate that specific phytochemical supplementation increased the effectiveness of the modified Mediterranean-style low glycemic load dietary program on variables associated with metabolic syndrome and CVD."

Lerman and colleagues published their study in Nutrition & Metabolism (Enhancement of a modified Mediterranean-style, low glycemic load diet with specific phytochemicals improves cardiometabolic risk factors in subjects with metabolic syndrome and hypercholesterolemia in a randomized trial. Nutrition & Metabolism, 2008;5():29).

Additional information can be obtained by contacting R.H. Lerman, MetaProteomics LLC, Functioning Med Research Center, 9770 44th Avenue, NW Ste. 100, Gig Harbor, WA 98332, USA.

The publisher of the journal Nutrition & Metabolism can be contacted at: Biomedical Central Ltd., Current Science Group, Middlesex House, 34-42 Cleveland St., London W1T 4LB, England.

Copyright © 2009 TB & Outbreaks Week via NewsRx.com


Copyright notice

This is a news service of NewsEdge Corporation ©2009. This content is for your personal use only, subject to Terms and Conditions. No redistribution allowed

About Soyatech  |   Advertising Services  |   Privacy Policy  |   Legal Notices  |   Contact Soyatech  |   Site Map